Heterozygous down-regulation of YAP inhibits CM cell cycle re-entry 7 days after TAC. WT and YAP-CHKO mice were subjected to either TAC or sham operation for 7 days. A, heart sections were stained with anti-Ki-67 (green), anti-troponin T (red), and DAPI (blue). The arrow indicates a Ki-67–positive CM. B, quantification of Ki-67–positive CMs (%) detected in WT and YAP-CHKO mouse hearts. n = 4. Values are mean ± S.D. *, p < 0.05 versus WT-sham; #, p < 0.05, comparison with WT-TAC and YAP-CHKO-TAC. Statistical analyses were conducted with ANOVA. Post hoc analysis was conducted with Tukey's test.