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. 2019 Mar 7;9:57. doi: 10.3389/fcimb.2019.00057

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Copyright © 2019 Yang, Yue and Xiong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Conditional knockout of Dpep2 in macrophages could markedly promote pro-inflammatory cytokine production in vivo. (A) Heart tissue homogenates were prepared on day 7 post CVB3 infection, and the levels of pro-inflammatory cytokines including TNF-α, IL-6, and MCP-1 were detected by real-time PCR. (B) Heart tissue homogenates were prepared on day 7, and the levels of pro-inflammatory cytokines including TNF-α, IL-6, and MCP-1 were detected by ELISA. Individual experiments were conducted three times with similar results and the representative data were shown. Data were presented as the means ± S.E.M. ^**p < 0.01; ^***p < 0.001.