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. 2019 Mar 13;18:1176935119835546. doi: 10.1177/1176935119835546

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© The Author(s) 2019

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 6. — UCSC shows clustering heatmaps to explore relationships between somatic mutation profiles, genomic subtypes, and survival. (A) Somatic mutations for the most significantly mutated genes in The Cancer Genome Atlas (TCGA) project AML tumour samples. Samples are arranged in rows and genes in columns. A strong concordance is observed between miRNA cluster 3 (orange), DNA methylation cluster 3 (also orange), and intermediate cytogenetic risk (light blue); and between miRNA cluster 5 (green), DNA methylation cluster 5 (also green), and favourable cytogenetic risk (dark blue). (B) Column 1 represents the miRNA expression clusters, Column 2 represents the DNA methylation clusters, and Column 3 represents cytogenetic risk category for the AML cohort.