Table 5.
Unmet needs in the rehabilitation of motor and respiratory function of LOPD patients.
| Unmet needs |
|---|
| Lack of definitions for adapted physical activity |
| Clinical and functional heterogeneity of LOPD patients |
| Poor identification of patients to whom protocols can be applied |
| Lack of guidelines based on well-grounded evidence |
| Poor identification of impairment and disability, also according to ICF classification |
| Lack of consensus on outcomes for clinical studies |
| Lack of different protocols for different clusters of patients |
| Modification of rehabilitation procedures on the basis of ERT |
| Evaluation of the influence of nutrition/supplementation on rehabilitation outcomes |
| Evaluation of the influence of the severity of pulmonary function impairment on rehabilitation programs for motor impairments |
| Lack of evidence on the safety of the specific rehabilitation procedures during the course of LOPD |
| Lack of definition of the rehabilitation approach according to current regulations – for instance, in Italy and in many European countries, ICF classification is required |
Abbreviations: ERT, enzyme replacement therapy; ICF, International Classification of Functioning, Disability and Health; LOPD, late-onset Pompe disease.