Table 2.

Lipoprotein Lipase–Modulating Proteins

	Effect on LPL Activity	Mechanism	Effect on Plasma TGs
Liver derived
ApoCI (50)	Inhibits LPL	Displace LPL from TG-rich particles	↑TG
ApoCII (51)	Activates LPL	Unclear	↓TG
ApoCIII (50)	Inhibits LPL	Displace LPL from TG-rich particles	↑TG
ApoA5 (48)	Activates LPL	Unclear	↓TG
ApoE (48)	Inhibits LPL	Unclear	↑TG
Angiopoietin-like proteins
ANGPTL 3 (52)	Inhibits LPL	Renders LPL more susceptible to proteolytic inactivation by proprotein convertases	↑TG
ANGPTL 4 (53)	Inhibits LPL	Inactivates LPL in the subendothelial space by binding to the LPL N-terminus and dissociating its catalytically active homodimers to monodimers	↑TG
ANGPTL 8 (54)	Inhibits LPL	May inhibit LPL activity directly or indirectly by promoting cleavage and activation of ANGPTL3	↑TG