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Types of Inherited IGHD
| Type | Inheritance | Serum GH | Development of GH Antibodies | Genes Involved |
|---|---|---|---|---|
| IA | AR | Absent | Frequent | GH1 (large deletions) |
| IB | AR | Low | No | GH1 (rare), GHRHR |
| II | AD | Low | No | GH1 (exon 3 deletion), GHRHR signal peptide mutation |
| III | X-linked | Low | No | Unknown |
Abbreviations: AD, autosomal dominant; AR, autosomal recessive.
