Table 3.

Physical Findings in Human GHRH Resistance (IGHD) and GH Resistance (Laron Syndrome)

Physical Findings	IGHD	Laron Syndrome
Neonatal size	Normal	Mildly reduced
Microphallus	Absent	Sometimes present
Short stature	Proportionate	Disproportional (lower limbs)
Final adult height	116 to 142 cm in males	117 to 137 cm in males
	108 to 136 cm in females	107 to 126 cm in females
Reduction of head	Less pronounced than height	Less pronounced than height
Facies	Doll: disproportion between the calvarium and the face	Doll: disproportion between the calvarium and the face
Hair	Sparse	Sparse
Skin	Wrinkled	Wrinkled
Voice	High-pitched	High-pitched
Obesity	More severe	Less pronounced
Bones	Smaller but strong	Smaller but strong
Muscular function	Appropriate	Reduced
Eyes	Shorter eyes, increased optic disc and vascular retinal hypoplasia	Shorter eyes, increased optic disc and vascular retinal hypoplasia