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. 2019 Mar 13;21(4):376–388. doi: 10.1016/j.neo.2019.02.002

Figure 4.

Figure 4

MRI of 4NQO-induced oral carcinogenesis in vivo. T2-weighted axial images of a representative C57BL/6 mouse from the control (4NQO group) and the three calcitriol treatment groups. Images are shown prior to 4NQO exposure (Week 0), 16 weeks post completion of 4NQO (Week 16) and at study end point (Week 26). The location of the exophytic oral lesions (outlined in yellow) and areas of thickening on the lateral borders of the tongue (arrows) are illustrated on the images. While exophytic lesions were seen in control, 4NQO → calcitriol and 4NQO + calcitriol → calcitriol regimens, animals treated with 4NQO + calcitriol did not show any evidence of exophytic lesions in the oral cavity on MRI.