FIGURE 1.

Conceptual flow diagram for agent-based model of multidrug-resistant organism (MDRO) transmission. Patients are admitted to the intensive care unit with a parameterized probability of MDRO colonization and receiving antibiotics. Patients receiving antibiotics are more likely to acquire and transmit a MDRO (microbiome effect) and can also acquire a MDRO via genetic mutation. Healthcare workers periodically visit patients during their stay and can colonize patients if they transiently acquire an MDRO from a colonized patient and transmit it to a susceptible patient prior to successfully cleaning their hands.