Figure 12.6.

Intracerebral treatment with the VRAC blocker DCPIB potently protects against ischemic brain damage in a rat model of stroke induced by 2-hour occlusion of the middle cerebral artery (MCAo). (A) Representative images of brain sections prepared from MCAo animals after intracerebral injection of vehicle (DMSO) or 20 μg/kg DCPIB. (B) Brain sections from MCAo animal which were treated systemically with intravenous injection of vehicle or 10 mg/kg DCPIB. Animals were euthanized 3 days after ischemia and the extent of brain infarction was revealed by staining brain sections with 2,3,5-triphenyltetrazolium chloride (viable tissue is red). Modified from Y. Zhang et al., 2008, with permission.