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. 2019 Mar 14;2019(3):CD010748. doi: 10.1002/14651858.CD010748.pub2

Summary of findings 2. Work‐directed counselling compared to usual care for people with coronary heart disease.

Work‐directed counselling compared to usual care for people with coronary heart disease
Patient or population: people with coronary heart disease
 Setting: hospital/home
 Intervention: work‐directed counselling
 Comparison: usual care
Outcomes Anticipated absolute effects* (95% CI) Relative effect
 (95% CI) № of participants
 (studies) Certainty of the evidence
 (GRADE) Comments
Risk with usual care Risk with work‐directed counselling
Days until return to work   The mean time to return to work was 7.52 days lower
 (20.07 lower to 5.03 higher) 618
 (4 RCTs) ⊕⊕⊝⊝
 Low1,2 Work‐directed counselling may result in little to no difference in days until return to work
Adverse effects: cardiac deaths
 Follow‐up mean: 6 months 2 per 100 2 per 100
 (0 to 8) RR 1.00
 (0.19 to 5.39) 388
 (2 RCTs) ⊕⊕⊕⊝
 Moderate3 Work‐directed counselling probably results little or no difference in cardiac death rates
*The risk in the Intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
 
 CI: confidence interval; RCT: randomised controlled trial; RR: risk ratio
GRADE Working Group grades of evidenceHigh certainty: we are very confident that the true effect lies close to that of the estimate of the effect.
 Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different.
 Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect.
 Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect.

1Downgraded one level due to substantial heterogeneity that we could not completely explain.
 2Downgraded one level due to imprecision (two of the four studies did not report the standard deviation).
 3Downgraded one level due to imprecision (pooled confidence interval is wide and includes either a possible harm or benefit).