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. 2019 Mar 14;2019(3):CD010748. doi: 10.1002/14651858.CD010748.pub2

Carson 1982.

Methods Study design: parallel RCT
Recruitment: men with MI who were admitted to CCU
Allocation: not reported
Blinding: not reported
Randomisation: not reported
Follow‐up(s): 3.5 years
Description: supervised exercise programme (12 weeks, 2 x/week)
Participants Baseline characteristics
Intervention group
  • Mean age (SD): 50.3 (0.65)

  • Sex (male %): 100

  • Number of participants randomised: 151

  • Working before CHD: not reported


Control group
  • Mean age (SD): 52.8 (0.67)

  • Sex (male %): 100

  • Number of participants randomised: 152

  • Working before CHD: not reported


Inclusion criteria
MI diagnosis based on ECG changes and/or elevation of SGOT or LD) taken on 3 consecutive days, and admitted to the CCU
Exclusion criteria
  • > 70 years of age

  • Heart failure at follow‐up clinic

  • Cardiothoracic ratio exceeding 59%

  • Severe chronic obstructive lung disease

  • Hypertension requiring treatment

  • Diabetes requiring insulin

  • Disabling angina during convalescence

  • Orthopaedic or medical disorders likely to impede progress in the gym

  • Personality disorders likely to render participant unsuitable for the course


Baseline imbalances:
Physically demanding work (i.e. white‐ vs blue‐collar): unknown
Severity of CHD: severe (prevalence of angina reported)
Interventions Intervention characteristics
Exercise
  • Circuit based training twice a week

  • Isometric exercise was avoided

  • Participants were advised to maintain their fitness by continuing with similar exercises or with other methods of their choice after course completion

  • Duration of intervention: 12 weeks

  • Providers: physician, physical educationalist


Control group
  • no training provided

Outcomes Not enough information provided to be included in the meta‐analysis (number of study participants working before MI):
Quote: "Eighty‐one per cent of both exercise and control groups who were working before MI returned to work after MI. There was no significant difference between the two groups in the mean time of return to work following MI (exercise 13 weeks, control 12 weeks)."
Adverse events (mortality)
Identification Sponsorship source: DHHS (Department of Health and Social Security)
Country: UK
Setting: single‐centre, outpatient (hospital gym)
Possible conflicts of interest: no information provided
Ethics committee approval: not reported
Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Quote: “The 303 patients who accepted were then randomly allocated to an exercise group (151) and a control group (152).” No further information provided.
Allocation concealment (selection bias) Unclear risk No information provided
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Due to the nature of the study, blinding of participants was not possible.
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk It is not clear how work status was assessed
Incomplete outcome data (attrition bias) 
 All outcomes High risk The study authors write, "eighty‐one per cent of both exercise and control groups who were working before MI returned to work after MI", but do not state at what within what time‐frame or at which rate they returned to work. Study follow‐ups were done at 5 months, 1, 2 and 3 years after the MI, but the loss‐to follow‐up is unclear. It is also unclear how many study participants were working prior to the MI.
Selective reporting (reporting bias) Unclear risk Unable to determine, no study protocol available
Other bias Unclear risk None identified