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. 2019 Mar 14;2019(3):CD010748. doi: 10.1002/14651858.CD010748.pub2

Hämäläinen 1991.

Methods Study design: parallel RCT
Recruitment: patients < 65 years of age, treated for their first AMI at 1 of 5 hospitals; April 1978‐March 1980
Allocation: randomly
Blinding: not reported
Randomisation: not reported
Follow‐up(s): 1, 2, 3 months, 1 and 6 years
Description: 2‐week inpatient combined rehabilitation programme
Participants Baseline characteristics
Intervention group (residential rehabilitation)
  • Mean age (SD): ‐

  • Sex (male %): 77

  • Number of participants: 228

  • Working before CHD: no information provided


Intrvention group (hospital outpatient)
  • Mean age (SD): ‐

  • Sex (male %): 77

  • Number of participants: 228

  • Working before CHD: no information provided


Inclusion criteria
  • < 65 years of age

  • Diagnosed MI following the WHO criteria

  • Treated for their first definite AMI

  • Survived the hospital phase


Exclusion criteria
Baseline imbalances:
Physically demanding work (i.e. white vs. blue collar): unknown
Severity of CHD: unknown
Interventions Intervention characteristics
  • Residential rehabilitation group:

    • Medical examination with blood tests, chest X‐ray, ECG, 24‐h ECG and cycle ergometer exercise test

    • A physiotherapist advised on how to continue physical exercise at home

    • Dietary counselling consisted of nutrition classes

    • A doctor guided 2 sessions about risk factors, MI, medication, and rehabilitation

    • A psychologist discussed psychic and social consequences of heart attack

  • Duration of intervention: 2 weeks

  • Providers: psychologists, diet specialists, physiotherapists, physician


Control group
  • Hospital outpatient care with visits to the coronary outpatient clinic 1, 2, and 3 months after AMI, and also later if medical problems arose. The coronary clubs of local Heart Associations provided patient education and arranged exercise groups. The main emphasis was however on outpatient clinic visits.

Outcomes Proportion at work at 6 months–12 months: 12 months
Adverse events (mortality, reinfarctions)
Identification Sponsorship source: not reported
Country: Finland
Setting: inpatient rehabilitation
Possible conflicts of interest: no information provided
Ethics committee approval: not reported
Notes Study authors write that only people who were working (also part‐time while receiving half‐pension), on sick leave, or unemployed at the time of their MI were included in the RTW analysis. The number of participants included in the analysis was provided, and the study authors could not be reached.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk No method of sequence generation is described.
Allocation concealment (selection bias) Unclear risk No method of allocation concealment is described.
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Due to the nature of this programme the blinding of participants was not possible.
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk No blinding of outcome assessors is described and it is unclear how employment status/RTW was determined.
Incomplete outcome data (attrition bias) 
 All outcomes Unclear risk Quote: "The participation rates at the check‐ups were 97%, 92%, and 89% at 1, 3, and 6 years"; no overall allocation of dropouts between intervention and control group indicated.
Selective reporting (reporting bias) Unclear risk Unable to determine, no study protocol was available
Other bias Unclear risk None identified