Table 6.
Results of the SMR analysis conducted using blood mQTLs and summary statistics from an endometriosis meta-analysis
| CHR | DNAm probe Site ID | Closest TSS gene name | Probe bp | Top SNP | Top SNP bp | A1 | b_SMR | p_SMR | p_HET |
|---|---|---|---|---|---|---|---|---|---|
| 2 | cg02584498 | GREB1 | 11,674,057 | rs77294520 | 11,660,955 | C | 0.149038 | 1.01E-11 | 0.009952231 |
| 2 | cg10849854 | GREB1 | 11,674,557 | rs77294520 | 11,660,955 | C | 0.250387 | 4.40E-10 | 0.000121199 |
| 4 | cg10360906 | KDR | 56,023,751 | rs11936364 | 56,019,253 | T | − 0.075528 | 2.43E-09 | 0.000696251 |
| 4 | cg01777861 | KDR | 56,023,843 | rs7696256 | 56,023,747 | G | − 0.096417 | 3.38E-09 | 0.000267448 |
| 4 | cg09978860 | KDR | 56,023,921 | rs11936364 | 56,019,253 | T | − 0.0974429 | 3.70E-09 | 0.000221536 |
| 1 | cg25011003 | WNT4 | 22,470,341 | rs55938609 | 22,470,451 | C | 0.280871 | 4.71E-09 | 0.181277 |
| 4 | cg16572876 | KDR | 56,024,045 | rs11936364 | 56,019,253 | T | − 0.144697 | 1.17E-08 | 0.000408871 |
| 4 | cg20092376 | KDR | 56,023,423 | rs6837695 | 56,015,840 | T | − 0.148622 | 1.17E-08 | 0.000631242 |
| 4 | cg07123701 | KDR | 56,024,434 | rs11936364 | 56,019,253 | T | − 0.151501 | 1.29E-08 | 0.000349096 |
| 2 | cg16908938 | GREB1 | 11,728,079 | rs59129126 | 11,728,388 | C | 0.0779192 | 1.34E-08 | 0.04232295 |
| 2 | cg07314298 |
Metazoa
_SRP |
11,723,111 | rs59129126 | 11,728,388 | C | 0.105449 | 1.88E-08 | 0.1823231 |
| 1 | cg15582954 | WNT4 | 22,470,343 | rs55938609 | 22,470,451 | C | 0.361317 | 7.96E-08 | 0.3437667 |
| 11 | cg26197155 | C11orf46 | 30,344,725 | rs12271187 | 30,319,259 | A | − 0.112429 | 1.71E-07 | 0.8086896 |