Table 7.

Top hallmark and GO biological processes pathways enriched for genes closest to DNAm probe sites in cis-mQTLs in endometrium and blood

Tissue	GeneSet	N	n	P value	Adjusted P
Endometrial mQTLs	Go intracellular signal transduction	1568	237	1.92E-29	5.50E-26
	Go regulation of multicellular organismal development	1667	247	2.48E-29	5.50E-26
	Go regulation of transport	1799	257	5.10E-28	7.54E-25
	Go regulation of cell differentiation	1488	224	1.29E-27	1.43E-24
	Go regulation of cell proliferation	1492	221	2.73E-26	2.42E-23
	Go neurogenesis	1401	211	4.37E-26	3.23E-23
	Go regulation of cell death	1471	218	5.66E-26	3.58E-23
	Go locomotion	1111	179	1.16E-25	6.41E-23
	Go positive regulation of molecular function	1786	248	3.00E-25	1.48E-22
	Go regulation of transcription from rna polymerase ii promoter	1780	246	9.31E-25	4.13E-22
	Hallmark uv response dn	144	37	9.77E-13	4.88E-11
	Hallmark oestrogen response early	200	41	1.94E-10	4.84E-09
	Hallmark epithelial mesenchymal transition	199	34	6.07E-07	8.57E-06
	Hallmark complement	200	34	6.86E-07	8.57E-06
	Hallmark androgen response	100	21	1.68E-06	9.69E-06
	Hallmark hypoxia	200	33	1.94E-06	9.69E-06
	Hallmark allograft rejection	200	33	1.94E-06	9.69E-06
	Hallmark il2 stat5 signalling	200	33	1.94E-06	9.69E-06
	Hallmark p53 pathway	200	33	1.94E-06	9.69E-06
	Hallmark myogenesis	200	33	1.94E-06	9.69E-06
Blood mQTLs	Go intracellular signal transduction	1568	330	9.02e-46	4.00e-42
	Go positive regulation of molecular function	1786	345	2.00e-39	4.44e-36
	Go neurogenesis	1401	291	3.12e-39	4.62e-36
	Go regulation of multicellular organismal development	1667	326	2.39e-38	2.29e-35
	Go regulation of hydrolase activity	1325	278	2.58e-38	2.29e-35
	Go regulation of intracellular signal transduction	1651	322	1.23e-37	9.08e-35
	Go positive regulation of catalytic activity	1515	302	3.82e-37	2.12e-34
	Go tissue development	1508	301	3.91e-37	2.12e-34
	Go locomotion	1111	244	4.78e-37	2.12e-34
	Go regulation of cell differentiation	1488	298	4.79e-37	2.12e-34
	Hallmark uv response dn	144	48	5.31e-16	2.66e-14
	Hallmark oestrogen response early	200	56	1.74e-14	4.35e-13
	Hallmark epithelial mesenchymal transition	199	48	3.49e-10	5.25e-09
	Hallmark complement	200	48	4.20e-10	5.25e-09
	Hallmark oestrogen response late	200	46	4.04e-09	4.04e-08
	Hallmark myogenesis	200	45	1.20e-08	1.00e-07
	Hallmark mitotic spindle	200	44	3.48e-08	2.49e-07
	Hallmark p53 pathway	200	43	9.80e-08	6.12e-07
	Hallmark apical junction	199	42	2.32e-07	1.22e-06
	Hallmark tnfa signalling via nfkb	200	42	2.68e-07	1.22e-06