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. 2019 Mar 12;38:126. doi: 10.1186/s13046-019-1105-3

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — miR-137 inhibits pancreatic cancer cell stemness in vitro. a miR-137 upregulation dramatically decreased the size and number of spheres formed in AsPC-1 and PANC-1 cell cultures, while anti-miR-137 had the opposite effect (p < 0.05). b-c Overexpression of miR-137 decreased the CD133⁺ population in cultured AsPC-1 and PANC-1 cells. In contrast, anti-miR-137 increased the CD133⁺ population in both cell lines (p < 0.05).d-e Overexpression of miR-137 markedly downregulated the expression of pluripotency-related mRNAs and proteins (p < 0.05), whereas miR-137 knockdown significantly upregulated the expression of these markers (p < 0.05)