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. 2019 Mar 12;19:31. doi: 10.1186/s12902-019-0357-4

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Smoothing splines of HbA1c and bone biochemical markers generated in generalized additive models. General associations between HbA1c and N-MID osteocalcin (a), and PICP (b); PTH (c), and β-CTX (d); 25(OH)D₃ (e). Adjusted for age, BMI, menopause’s years, diabetic duration, TC, TG, HDL-c, LDL-c, creatinine, UA, and eGFR. The line of dark blue circles indicates 95% confidence intervals