Fig. 1.

Genome-wide DNA methylation changes in breast cancer. a Stacked bar plot showing localization of the 368 differentially-methylated CpG sites in breast tumor tissue relative to their cognate genes. b Stacked bar plot showing localization of hyper- and hypomethylated CpG sites in breast tumor tissue relative to their cognate genes. The distributions are significantly different (P < 2.2e^− 16, Pearson’s chi-squared test). c and d Enriched Gene Ontology categories using DAVID clustering enrichment scores for genes c hypermethylated or d hypomethylated in tumors. TSS1500, within 1500 bp of the transcriptional start site; TSS200, within 200 bp of the transcriptional start site; 5’UTR, 5′ untranslated region; 3’UTR, 3′ untranslated region