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. 2019 Mar 12;20:54. doi: 10.1186/s13059-019-1645-z

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© The Author(s) 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Clone-specific gene expression in high-grade serous ovarian cancer cell lines. a Single-cell phylogeny for the OV2295R and TOV2295R HGSC cell lines inferred using a Latent Tree Model divided into four clones (TOV2295R_A, TOV2295R_B, OV2295R_C, OV2295R_D). b The scRNA-seq clone assignments for the four clone model (top), then sub-divided into eight clones (bottom). c Expression-CNA relationship on two held out chromosomes for TOV2295R validates the clonealign fit. d Top differentially expressed genes between clones in TOV2295R and e OV2295R