Fig. 5.

Loss of NAP1 suppresses HSP90-mediated metastasis of NSCLC cells in mice. (a) Tumor growth measured by tumor volume within 42 days. (b-d) Tumor (b) and lung (c) weight and the number of pulmonary nodules (d) measured on day 42. (e) Lung micro-metastasis determined by H&E staining. The six-week old NSG mice were randomly assigned to four groups (n = 5) to receive H661 cells carrying the indicated gene modifications. EV: empty vector; HSP90 O/E: the HSP90 gene overexpressing vector; shNAP1: shRNA against the NAP1 gene. *p < 0.05; **p < 0.01