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. 2019 Mar 14;16:62. doi: 10.1186/s12974-019-1450-3

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — UA counteracted cognitive decline in APP/PS1mice. a The escape latency in the spatial learning test. b The average swimming speed among all the groups. c The percentage of time spent in the target quadrant in the probe test. d The number of crossings through the target quadrant (where the platform was previously located) in the probe test. e Representative path tracings in each quadrant during the probe trial. All data are presented as the mean ± SEM, n = 8–10 mice per group. **P < 0.01; WT wild-type, UA urolithin A