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. 2019 Mar 12;17:78. doi: 10.1186/s12967-019-1831-5

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Left panels—examples of reconstructed normalized volumes obtained after the administration of ¹²³I ioflupane in sham versus stimulated animals. The colors represented pixel-wise modeled SPECT dynamic image series according to Ichise i.e., the binding potential overlaid on the MRI template of the pig brain atlas. Red VOIs corresponded to DAT-rich areas whereas yellow VOIs represented SERT-rich areas. Right panel—binding potential for DAT and SERT in sham versus stimulated groups obtained from region-based analysis. *Indicates a significant difference at P < 0.001