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. 2019 Mar 12;11:48. doi: 10.1186/s13148-019-0645-x

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Several histone modifications altered in breast cancer development. a Workflow for the whole project, including mice mating, LC-MS/MS screening, Western blot validation, and ChIP-seq analysis. b Overview of quantified histone PTMs in core histone proteins in breast tissues. c Heat map of quantified histone marks found to be regulated in tumor tissue as compared to normal tissue. d Volcano plots representing the fold change (x-axis) and the significance (y-axis) for single histone marks. The statistical difference is calculated using the t test. The two histone marks H3K4me3 and H3K27ac marked with asterisk (*) were only detected in tumor by MS analysis. e Western blot analysis with the indicated histone marks antibodies. Whole tissue lysates were prepared from normal tissue or tumor 3 replicates