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. Author manuscript; available in PMC: 2019 Mar 14.
Published in final edited form as: Nat Struct Mol Biol. 2010 Jan;17(1):5–10. doi: 10.1038/nsmb.1762

Figure 1.

Figure 1

A general model of miRNA biogenesis and function6–9. After synthesis by RNA polymerase II, miRNA primary transcripts are recognized by Pasha/DGCR8 and Drosha, which excises the hairpin precursor. Exportin 5 delivers the miRNA precursor to Dicer and its RNA binding partner, TRBP/Loqs, for final processing to the mature 22-nt miRNAs. One strand is selected for stable association with Argonaute, where it serves as a guide to target and regulate specific mRNAs.