Table 5.
The medium to long term (two-year) predictability of subject and study partner CFI by baseline CDR
| Subjects | All Sample |
CDR = 0 |
CDR = 0.5 |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Estimate | 95% CI | Odds Ratio | p | Estimate | 95% CI | Odds Ratio | p | Estimate | 95% CI | Odds Ratio | p | ||||
| CFI from two years ago | 0.241 | 0.145 | 0.337 | 4.92 | <0.0001 | 0.301 | 0.166 | 0.435 | 4.39 | <0.0001 | 0.088 | −0.028 | 0.204 | 1.49 | 0.136 |
| Two-year change of CFI | 0.177 | 0.051 | 0.303 | 2.76 | 0.006 | 0.279 | 0.118 | 0.439 | 3.40 | 0.001 | 0.037 | −0.140 | 0.213 | 0.41 | 0.684 |
| mMMSE score from two years ago | −0.198 | −0.245 | −0.151 | −8.33 | <0.0001 | −0.224 | −0.282 | −0.167 | −7.62 | <0.0001 | −0.153 | −0.236 | −0.070 | −3.63 | <0.0001 |
| FCSRT score from two years ago | −0.128 | −0.225 | −0.032 | −2.60 | 0.009 | −0.080 | −0.202 | 0.042 | −1.28 | 0.200 | −0.561 | −0.891 | −0.232 | −3.34 | 0.001 |
| Age at baseline | 0.098 | 0.042 | 0.155 | 3.44 | 0.001 | 0.049 | −0.026 | 0.124 | 1.28 | 0.200 | 0.164 | 0.064 | 0.265 | 3.20 | 0.001 |
| Ethnicity | 0.274 | −0.305 | 0.853 | 0.93 | 0.353 | 0.006 | −0.707 | 0.718 | 0.02 | 0.988 | 0.867 | −0.186 | 1.920 | 1.61 | 0.107 |
| Subjects’ language | 0.345 | −0.423 | 1.113 | 0.88 | 0.379 | 0.122 | −0.842 | 1.086 | 0.25 | 0.804 | 0.976 | −0.716 | 2.669 | 1.13 | 0.258 |
| CDR Global score at baseline | 0.929 | 0.398 | 1.461 | 3.43 | 0.001 | ||||||||||
| Study Partner | |||||||||||||||
| CFI from two years ago | 0.152 | 0.059 | 0.245 | 3.20 | 0.001 | 0.280 | 0.171 | 0.390 | 5.02 | <0.0001 | −0.001 | −0.132 | 0.130 | −0.01 | 0.989 |
| Two-year change of CFI | 0.226 | 0.137 | 0.315 | 4.96 | <0.0001 | 0.248 | 0.141 | 0.355 | 4.55 | <0.0001 | 0.170 | 0.013 | 0.327 | 2.12 | 0.034 |
| mMMSE score from two years ago | −0.201 | −0.246 | −0.155 | −8.61 | <0.0001 | −0.232 | −0.285 | −0.180 | −8.65 | <0.0001 | −0.179 | −0.264 | −0.095 | −4.16 | <0.0001 |
| FCSRT score from two years ago | −0.125 | −0.233 | −0.016 | −2.25 | 0.025 | −0.050 | −0.197 | 0.097 | −0.67 | 0.503 | −0.590 | −0.935 | −0.245 | −3.35 | 0.001 |
| Age at baseline | 0.083 | 0.028 | 0.139 | 2.93 | 0.003 | 0.028 | −0.043 | 0.099 | 0.78 | 0.436 | 0.166 | 0.062 | 0.270 | 3.12 | 0.002 |
| Ethnicity | 0.238 | −0.398 | 0.873 | 0.73 | 0.464 | −0.166 | −0.931 | 0.599 | −0.43 | 0.671 | 1.009 | −0.036 | 2.053 | 1.89 | 0.058 |
| Subjects’ language | 0.172 | −0.602 | 0.946 | 0.44 | 0.663 | 0.110 | −0.909 | 1.129 | 0.21 | 0.832 | 0.736 | −1.068 | 2.539 | 0.80 | 0.424 |
| CDR Global score at baseline | 0.947 | 0.423 | 1.470 | 3.55 | <0.0001 | ||||||||||
CFI, Cognitive Function Instrument; mMMSE, Modified Mini-Mental State Exam; FCSRT, Free and Cued Selective Reminding Test; CDR, Clinical Dementia Rating.