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. 2019 Mar 7;10:390. doi: 10.3389/fimmu.2019.00390

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Copyright © 2019 Hussain, Hargreaves, Rowley, Sopp, Latham, Bhatta, Sherington, Cutler, Humphreys, Glennie, Strefford and Cragg.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impact of FcγR polymorphisms on IFN-γ release induced by IgG1 Fc Hexamer stimulation in a whole blood assay format. Healthy donors were grouped by; (A) FcγRIIa polymorphisms; HH (n = 25), R/H (n = 41), and RR (n = 22), (B) FcγRIIIa polymorphisms; VV (n = 12), FV (n = 49) and FF (n = 27), (C) high affinity FcγR polymorphisms HH/VV (n = 5) and low affinity FcγR polymorphisms RR/FF (n = 8), (D) FcγRIIc polymorphisms; Q carriage (n = 26) and XX (n = 62), (E) FcγRIIIb polymorphisms; AA (n = 9), AB (n = 45) and BB (n = 34) and (F) FcγRIIb polymorphisms; II (n = 70) and IT (n = 18). Whole blood from each donor was stimulated with IgG1 Fc Hexamer and IFN-γ release was quantified 24 h post-stimulation. Each point represents a donor, bars represent group geometric means. *p < 0.05.