Table 4. Individual toxicity contributions and DTI for drugs discussed in the main text.
| Drug | Toxicity contributions |
DTI | |||||
| PD on target | PD off target |
PK | Log D (physicochemical) | ||||
| CYP450 | hERG | BSEP | |||||
| Troglitazone (400 mg) | 0.08 | 2.36 | 0.00 | 2.51 | 1.12 | 11.64 | 1.25 |
| Troglitazone (200 mg) | 0.04 | 0.00 | 1.25 | 1.00 | 1.18 | 5.82 | 0.97 |
| Pioglitazone | 0.08 | 0.34 | 0.00 | 1.99 | 0.28 | 0.14 | 0.45 |
| Terfenadine | 4.24 | 4.05 | 1.49 | 0.00 | 0.08 | 6.91 | 1.22 |
| Fexofenadine | 0.56 | 0.00 | 0.10 | 0.00 | 0.05 | 0.01 | –0.15 |
| Telotristat ethyl | 0.01 | 0.96 | 0.99 | 0.00 | 28.99 | 3.54 | 1.54 |
| Enasidenib | 0.02 | 0.00 | 0.40 | 0.00 | 0.03 | 2.84 | 0.52 |
| Brivaracetam | 7.56 | 0.00 | 0.00 | 0.00 | 12.79 | 0.50 | 1.32 |
| Cariprazine | 1.25 | 0.00 | 0.00 | 0.00 | 15.24 | 0.74 | 1.24 |