Table 1. Complexity of models.

Runtimes and number of variables for different state distributions and for 2, 3 and 4 states for covariate model 1. Runtimes are on Intel Xeon E5-2697v2 @ 2.7 GHz.

	No. of variables	Range of runtime	Average of runtime
Correlated log-normal
2-state	28	0.9–3 (min)	1.9 (min)
3-state	63	2.25–15 (min)	7.3 (min)
4-state	112	1–2.4 (hrs)	1.6 (hrs)
Correlated gamma
2-state	28	1.14–9.30 (min)	5.65 (min)
3-state	63	17.25–86.81 (min)	54.88 (min)
Independent log-normal
2-state	26	0.11–3.66 (min)	1.28 (min)
3-state	60	3–12.56 (min)	5.7 (min)
4-state	108	1–3 (hrs)	1.88 (hrs)
Independent Gamma
2-state	26	1.58–3.57 (min)	2.43 (min)
3-state	60	11.81–26.35 (min)	15.53 (min)