. 2019 Mar 14;14(3):e0212586. doi: 10.1371/journal.pone.0212586

Table 3. P and R values from clustering analysis using the Adonis and ANOSIM tests using unweighted and weighted UniFrac distances.

	Unweighted UniFrac
	Apple supplementation (with vs without)^a	Diet (HF vs LF)^b	Treatment (HF and LF with and without supplementation)^c
Adonis	P = 0.071	P = 0.001	P < 0.001
ANOSIM	P = 0.071 (R = 0.07)	P = 0.001 (R = 0.69)	P = 0.001 (R = 0.54)
	Weighted UniFrac
Adonis	P = 0.072	P = 0.011	P = 0.005
ANOSIM	P = 0.129 (R = 0.05)	P = 0.028 (R = 0.19)	P = 0.009 (R = 0.18)

Results are shown from the comparison of all samples with (n = 18) and without (n = 14) apple supplementation, regardless of diet^a; from the comparison between the high-fat (HF, n = 22) and the low-fat (LF, n = 10) group, regardless of apple supplementation^b; and from the comparison of all four treatment groups^c. These results are consistent with the clustering of samples in Fig 6.