Fig 4. roX2 binding locations and sequence motifs.

(A) RoX2-bound regions are highly enriched on both the ancestral X chromosome and the neo-X chromosome in all three species. Underlying data can be found in S4 Data. (B) Identification of MSL binding motif. From the strongly bound peaks corresponding to CESs, we identified a GA-rich sequence motif on both the ancestral X and neo-X chromosome in all three species. The gray boxes highlight the conserved core motif, which is very similar to that found in D. melanogaster. CES, chromatin entry site; MSL, male-specific lethal.