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. Author manuscript; available in PMC: 2019 Mar 14.
Published in final edited form as: Pac Symp Biocomput. 2019;24:8–17.
Open Access chapter published by World Scientific Publishing Company and distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC) 4.0 License (http://creativecommons.org/licenses/by-nc-nd/4.0/).