Figure 4. Ethanol and caffeine effects on diameter of de-endothelialized cerebral arteries in presence of TRPV1 antagonist.
A. Averaged percent changes in artery diameter evoked by 50 mM ethanol in absence (n=7) versus presence (n=5) of TRPV1 blocker, and by 10 μM caffeine in absence (n=11) versus presence (n=4) of TRPV1 blocker. Ethanol and caffeine data were tested separately using non-paired Student’s t-test. **Statistically significant difference; P =0.0025 for ethanol; P=0.0973 for caffeine. B. Averaged percent changes in artery diameter evoked by 50 mM ethanol mixture with 10 μM caffeine in absence (n=4) versus presence (n=5) of TRPV1 blocker 100 nM A 784168. Data were tested using non-paired Student’s t-test.
**Statistically significant difference; P =0.0076.