Table 1.

Treatment regimens

Treatment regimens	Clinician-administered loading dose (mg)	Demand dose via PCA (mg)	Clinician-administered supplemental dose (mg)
Placebo	Volume-matched	Volume-matched	Volume-matched
Oliceridine 0.1 mg regimen	1.5	0.1	0.75
Oliceridine 0.35 mg regimen	1.5	0.35	0.75
Oliceridine 0.5 mg regimen	1.5	0.5	0.75
Morphine 1 mg regimen	4	1	2

Notes: Clinician-administered supplemental dosing could start 1 hour after the loading dose and be administered up to hourly, as needed. Further open-label rescue pain medication (oral etodolac 200 mg every 6 hours) was permitted, as needed. PCA had a 6-minute lockout.

Abbreviation: PCA, patient-controlled analgesia.