Table 3.
Overview of Au-NPs/DOX, Au-NPs/paclitaxel (PTX), and their applications
| NPs | Drugs/targeting agent | Applications | References |
|---|---|---|---|
| Au-NPs pectin (Pec-Au-NPs) | DOX | Breast cancer cells | 57 |
| DOX-loaded fucoidan-capped Au-NPs | DOX | Human breast cancer cells | 54 |
| Protein-gold cluster-capped mesoporous silica NPs | DOX/gemcitabine | A549 lung cancer cells | 58 |
| Gelatin-DOX conjugate (GLT-DOX)-coated Au-NPs (DOX-GLT/EGCG Au-NPs) | DOX | PC-3 cancer cell | 59 |
| Biosynthesized Au-NP Peltophorum pterocarpum | DOX | Cancer cells (A549, B16F10) and tumor growth in an in vivo model | 60 |
| Gelatin-coated Au-NPs | DOX | MCF-7 breast cancer cells | 61 |
| Au-NPs/polyvinylpyrrolidone | DOX | A549, H460, and H520 lung cancer cells | 55 |
| DOX-loaded Au-NPs | DOX | A2780 human ovarian cancer cell line | 56 |
| Pectin-capped Au-NPs | DOX | Human Caucasian hepatocyte cells | 62 |
| Human serum albumin (HSA)-coated gold nanorods (GNR/PSS/HSA NPs) | DOX | Combined cancer photothermal therapy and chemotherapy | 63 |
| Gold nanoplatform targeting carbonic anhydrase IX epitope | DOX | HT29 tumor cells | 64 |
| Oligonucleotide-conjugated Au-NP | DOX | SW480 cells | 65 |
| Oligonucleotides attached to Au-NP | DOX | SW480 | 65 |
| Colloidal Au-NPs | DOX | HepG2 | 66 |
| Au/Fe3O4 | DOX | Targeted chemo-photothermal | 67 |
| Cisplatin and DOX-bioconjugated bromelain-encapsulated Au-NPs | DOX | MG-63 and Saos-2 | 68 |
| Platinum (core)-gold (shell) bimetallic NPs with chitosan | DOX | HEK293, Caco-2, HepG2, and MCF-7 | 69 |
| Magnetic and Au-NP-embedded silica nanoshuttles | DOX | HeLa | 70 |
| Ultrasmall Au-NPs were appended to the openings of mesoporous silica NPs | DOX | A549 | 71 |
| Multifunctional Au-NP | DOX | A549 | 72 |
| Fetuin-conjugated Au-NPs | DOX | NCI-H460 | 73 |
| Au-NPs coated | DOX | VX2 and raw 264.7 | 74 |
| Asialoglycoprotein receptor/PTX-conjugated Au-NPs | PTX | Liver tumor (HepG2) cells | 75 |
| Gold NP-coated pluronic-b-poly(l-lysine) NPs | PTX | MDA-MB-231 cells | 76 |
| Au-NPs with two-layer (hexadecanethiol/phosphatidylcholine) and three-layer (with high-density lipoprotein) NPs | PTX | Lung cancer | 77 |
| Biocompatible Au-NPs/chitosan oligosaccharide | PTX | MDA-MB-231 | 78 |
| Gold-PTX nanoconjugate | PTX | H460 and H460PTX | 79 |
| Dithiocarbamate-functionalized PAMAM dendrimer used to cross-link the shell of arginine Au-NPs | PTX | B16F10 cells | 80 |
| Polymer-coated gold/graphene hybrid | PTX | MCF-7 and 16 HBE | 81 |
| Liposomes and Au-NPs used to construct a liposome with a hybrid cluster bomb structure | PTX | HepG2 | 82 |
| Multifunctional nanoparticulate theranostic system simultaneously encapsulating PTX, Au-NPs, and iron oxide NPs in poly(ethylene oxide)-block-poly(ε-caprolactone) | PTX | MCF-7 and MDA-MB-231 | 83 |
Abbreviations: Au-NPs, gold nanoparticles; DOX, doxorubicin; NPs, nanoparticles; PAMAM, poly(amidoamine); PTX, paclitaxel; HSA, human serum albumin; PSS, poly(sodium 4-styrenesulfonate).