Table 4.

Lagged associations between 3D measures of cardiac mechanics and 2D LVEF or E/e’ at subsequent visit

	Median (IQR)	2D LVEF Beta (95% CI)	P-value*	E/e’ Beta (95% CI)	P-value*
3D LVEF (%)	49.9 (43.6, 54.6)	1.6 (0.7, 2.6)	0.001	−0.1 (−0.4, 0.2)	0.54
GCS (%)	−22.0 (−25.7, −18.5)	−1.6 (−2.4, −0.7)	0.001	0.1 (−0.2, 0.5)	0.39
GLS (%)	−14.6 (−17.0, −12.3)	−1.3 (−2.3, −0.3)	0.010	−0.2 (−0.6, 0.2)	0.31
Principal strain (%)	−25.4 (−29.0, −21.7)	−1.5 (−2.5, −0.6)	<0.001	0.2 (−0.2, 0.5)	0.34
Twist (°)	9.0 (6.3, 12.5)	0.5 (−0.3, 1.4)	0.24	−0.2 (−0.6, 0.1)	0.15
Torsion (°/cm)	1.1 (0.8, 1.6)	0.5 (−0.3, 1.3)	0.20	−0.2 (−0.5, 0.1)	0.25

^*P-values are based on the Wald test.

All models were adjusted for 2D LVEF or E/e’ (depending upon the outcome of interest) at baseline, age, BMI, heart rate (time-varying), systolic blood pressure (time-varying), and time since baseline (modeled non-parametrically using cubic splines).

All echocardiographic parameters were standardized based on the interquartile range at the post-anthracycline visit. An example of the interpretation is noted in Table 2.

3D indicates three-dimensional; LVEF, left ventricular ejection fraction; GCS, global circumferential strain; and GLS, global longitudinal strain.