Table 2.
Social-communication assessments reported in PMS studies
| Measure | Standardized Age Range | Administration Method | Description and Domains | PMS Studies: Cohort Descriptions & Clinically Relevant Findings |
|---|---|---|---|---|
| Autism Diagnostic Observation Schedule (ADOS) (Lord et al. 2012) | >12 mos. | Direct testing by clinician; 40–60 minutes |
Toddler Module Module 1: pre-verbal/single words Module 2: phrased speech Module 3: complex speech Module 4: complex speech, late teens and adults. |
Scores N/A (n=1) (Dhar et al., 2010) |
|
Subjects meeting autism criteria: 23 Subjects meeting ASD criteria: 4 (n=32) (Soorya et al., 2013) | ||||
| Scores N/A.(n=2) (Serret et al., 2015) | ||||
| Scores N/A. (n=9) (Kolevzon, Bush, et al., 2014) | ||||
| Scores N/A. (n=24) (Mieses et al., 2016) | ||||
| Autism Diagnostic Interview Revised (ADI-R; Rutter, LeCouteur & Lord, 2003) | >2 yrs. | Parent/caregiver interview by clinician; 90–150 minutes |
Communication Reciprocal Social Interactions Repetitive Behaviors/Interests |
Scores N/A. (n=1) (Dhar et al., 2010) |
| Subjects meeting ASD criteria: 18 (n=30) (Soorya et al., 2013) | ||||
| Subjects meeting ASD criteria: 0 (n=8) (Philippe et al., 2008) | ||||
| Scores N/A. (n=2) (Serret et al., 2015) | ||||
| Scores N/A. (n=9) (Kolevzon, Bush, et al., 2014) | ||||
| ADI-R algorithm scores N/A (n=40) (Oberman et al., 2015) | ||||
| Gilliam Autism Rating Scale 3 (GARS-3) (Gilliam, 1995) | 3 – 22 yrs. | Parent or Teacher rated; 5–10 minutes | DSM-5 Autism Spectrum Disorder | Scores N/A. (n=1) (Dhar et al., 2010) |
| Childhood Autism Rating Scale (CARS) (Eric Schopler, Reichler, & Renner, 2002) | 2+ yrs. | Clinician rated; 5–10 minutes | Autism diagnosis | Scores N/A. (n=1) (Dhar et al., 2010) |
|
Subjects above ASD cutoff score: 17 (n=18) (Phelan et al., 2001) | ||||
|
Subjects above ASD cutoff score: 2 (n=2) (Serret et al., 2015) | ||||
| Social, Communication Questionnaire (SCQ) (Berument, Rutter, Lord, Pickles, & Bailey, 1999) | >4 yrs. (mental age: >2 yrs.) |
Parent/caregiver rated; 10 minutes |
Autism symptoms |
Subjects above ASD cutoff score: 23 (n=27) (Jeffries et al., 2005) |
| Pervasive Developmental, disorder in Mentally Retarded Persons (PDD-MRS) (Kraijer & de Bildt, 2005) | 2–55 yrs. | Parent/caregiver rated; 5–10 minutes |
Autism Risk |
Subjects scoring within PDD spectrum: 4 (n=7) (Denayer et al., 2012) |
AE = age equivalent
ASD = autism spectrum disorder
DSM-5 = Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition
Mos. = months
N/A = not available or not reported
PDD = pervasive developmental disorder
PMS = Phelan-McDermid Syndrome
Yrs. = years