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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Anesthesiology. 2019 Apr;130(4):592–608. doi: 10.1097/ALN.0000000000002615

Fig.2. TRPV1 antagonist capsazepine and AMG9810 induce a stronger inhibition of glutamate transmission and firing in LHb neurons from EtOH-WD rats.

Fig.2.

Representative traces of sEPSCs in the absence and presence of capsazepine (CPZ, A1) and AMG9810 (AMG, B1) in Naïve (●) and EtOH-WD (△) rats. Capsazepine and AMG9810 (0.1–100 μM) induced changes in the frequency (CPZ: A2, AMG: B2) and amplitude (CPZ: A3, AMG: B3) of sEPSCs. Example traces of firing in the absence and presence of capsazepine (C1) and AMG9810 (D1). Summary graph of inhibition induced by capsazepine (C2) and AMG9810 (D2). Capsazepine and AMG9810 produced a significantly greater inhibition on sEPSC frequency and firing rate in EtOH-WD rats. *P < 0.05, **P < 0.01, ***P < 0.001 relative to 0.1 μM CPZ/AMG. #P < 0.05, ##P < 0.01 Naïve in comparison with EtOH-WD rats. Data were analyzed with two-way ANOVA and Tukey post hoc comparison.