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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Anesthesiology. 2019 Apr;130(4):592–608. doi: 10.1097/ALN.0000000000002615

Fig. 5. Capsazepine mitigates hyperalgesia and spontaneous pain in ethanol-withdrawn rats.

Fig. 5.

(A) The paw withdrawal latency (PWL) to thermal stimuli was significantly reduced in EtOH-WD rats at 24hr withdrawal, in comparison to the Naïve counterparts. $$$P < 0.001 relative to respective baseline. Two-way RM ANOVA followed by Tukey post hoc comparison. (B) Intra-LHb injection of capsazepine (CPZ) significantly increased the nociceptive response in EtOH-WD rats. The change in nociceptive response is expressed as percent maximum peak effect (%MPE). Intra-LHb DNQX significantly increased PWL in both Naïve and EtOH-WD rats. (C) In the place conditioning paradigm, intra-LHb CPZ significantly increased the place conditioning score in EtOH-WD rats; intra-LHb DNQX significantly increased the CPP score in both Naïve and EtOH-WD rats. **P <0.01, ***P < 0.001 relative to respective aCSF treatment; ###P < 0.001 Naïve vs. EtOH-WD rats. The place conditioning score was significantly correlated with %MPE with intra-LHb DNQX (D), and CPZ (E) in EtOH-WD rats.