Table 3.

Multivariate analysis of OS, DFS and PFS in IECC cohort with respect to covariates age, FIGO stage, grade, tumor size and Silva pattern in the entire cohort, HPVA only and NHPVA groups.

Covariate	OS			DFS			PFS
	p value	HR	CI	p value	HR	CI	p value	HR	CI
All (HPVA and NHPVA)
HPV status	0.060	0.14	0.03–0.95	0.064	0.14	0.02–1.02	0.81	1.3	0.14–11
Age	0.95	1	0.96–1.05	0.77	1.01	0.96–1.05	0.97	1	0.96–1.04
Stage (I/II vs III/IV)	0.056	7.73	1.32–33.8	0.044	8.43	1.47–37.3	0.65	1.45	0.3–7.09
Grade (1 vs 2 vs 3)	0.34	3.42, 3.51	0.21–520, 0.27–494	0.39	2.55, 2.98	0.16–393, 0.23–416	0.067	0.37	0.13–1.08
Size	0.10	1.03	0.99–1.07	0.067	1.04	1–1.08	0.48	0.99	0.96–1.02
Silva pattern (A/ B vs C)	0.09	3.5	0.4–458	0.18	2.29	0.24–304	-	-	-
HPVA only
Age	0.83	1.01	0.96–1.05	0.63	1.02	0.96–1.06	0.96	1	0.96–1.04
Stage (I/II vs III/IV)	0.072	6.98	1.17–30	0.056	7.48	1.31–32	0.73	1.32	0.27–6.4
Grade (1 vs 2 vs 3)	0.95	0.33, 0.3	0–64, 0–65	0.99	0.32, 0.33	0–63, 0–74	0.072	0.38	0.13–1.1
Size	0.19	1.03	0.99–1.07	0.10	1.03	0.99–1.08	0.44	0.99	0.96–1.02
Silva pattern (A/B vs C)	0.086	4.14	-	0.18	2.58	-	-	-	-
NHPVA only
Age	0.032	1.06	1–1.1	0.052	1.09	1–1.18	0.51	1.02	0.96–1.1
Stage (I/II vs III/IV)	0.022	8×109	-	0.0044	5×1022	-	1	9×108	-
Grade (1 vs 2 vs 3)	0.54	0.35, 1.17	0.02–5.5, 0.18–7.4	0.098	0, 0.74	0.09–6.06	0.44	0.4	0.04–4.03
Size	0.0022	1.1	1.01–1.19	0.0035	1.1	1.01–1.2	0.27	1.04	0.97–1.1
Silva pattern (A/B vs C)	-	-	-	-	-	-	-	-	-