Table 1:
Cohort characteristics
| Characteristics | Entire cohort | Derivation cohort | Validation cohort |
|---|---|---|---|
| No. of hospitalizations1 (no. of patients) | 350,810 (230,764) | 180,757 (138,824) | 170,235 (132,800) |
| 30-day2 Rehospitalization rate, % | 12.1 | 12.0 | 12.2 |
| 30-day Rehospitalization or death composite rate, % | 14.9 | 14.8 | 15.0 |
| Male, % | 47.4 | 47.4 | 47.3 |
| Age (median, mean ± SD3) % ≥ 65 years |
67.0, 65.1 ± 17.4 55.9 |
67.0, 65.1 ± 17.3 55.8 |
67.0, 65.1 ± 17.4 55.9 |
| LAPS24 (median, mean ± SD) | 49.0, 55.6 ± 38.7 | 49.0, 55.6 ± 38.7 | 49.0, 55.5 ± 38.7 |
| COPS25 (median, mean ± SD) | 27.0, 45.6 ± 46.6 | 27.0, 45.6 ± 46.6 | 27.0, 45.6 ± 46.6 |
| RxDxCG (median, mean ± SD) | 3.26, 5.21 ± 6.32 | 3.26, 5.19 ± 6.30 | 3.26, 5.22 ± 6.35 |
| Charlson comorbidity score (median, interquartile range) | 0.00, 1.03, 2.00 | 0.00, 1.03, 2.00 | 0.00, 1.03, 2.00 |
There were no significant differences between the derivation and validation cohorts (all p-values were greater than 0.2)
The total number of hospitalizations exceeds total number of patients because individual patients could contribute more than one hospitalization to the dataset.
Ascertained primarily from Kaiser Permanente Medical Care Program hospitalization and patient demographic databases and probably slightly underestimates true rate.
Standard deviation
Laboratory Acute Physiology Score, version 2; an acute physiology-based score that includes lactate, vital signs, neurological status checks, and pulse oximetry. Increasing degrees of physiologic derangement are reflected in a higher LAPS2, which is a continuous variable that can range between a minimum of zero and a theoretical maximum of 414, although < 0.05% of patients in our cohort had a LAPS2 exceeding 227 and none had a LAPS2 > 282. Increasing values of LAPS2 are associated with increasing mortality 4.
COmorbidity Point Score, version 2; a longitudinal, diagnosis-based score assigned monthly that employs all diagnoses incurred by a patient in the preceding 12 months that results in a single continuous variable that can range between a minimum of zero and a theoretical maximum of 1,014, although < 0.05% of patients in our cohort had a COPS2 exceeding 241 and none had a COPS2 > 306. Increasing values of the COPS2 are associated with increasing mortality 4.