Table 2:
Aβ(1–42)-Induced Carbonylated Proteins in vivo
| Function | Protein | Model | Tissue | References |
|---|---|---|---|---|
| Antioxidants and Cellular Detoxification Defenses | Glutathione S-Transferase | Canineb | -- | Opii et al. 2008 |
| C. elegansb | -- | Boyd-Kimball et al. 2006 | ||
| Adenosine kinase | C. elegansb | -- | Boyd-Kimball et al. 2006 | |
| Arginine kinase | C. elegansb | -- | Boyd-Kimball et al. 2006 | |
| Glutamate dehydrogenase | Canineb | -- | Opii et al. 2008 | |
| Lipid binding protein | C. elegansb | -- | Boyd-Kimball et al. 2006 | |
| Energy Metabolism | acyl-CoA DH (medium chain) | C. elegansb | -- | Boyd-Kimball et al. 2006 |
| acyl-CoA DH (short-chain) | C. elegansb | -- | Boyd-Kimball et al. 2006 | |
| α-enolase | Canineb | -- | Opii et al. 2008 | |
| Glyceraldehyde-3-phosphate dehydrogenase | Canineb | -- | Opii et al. 2008 | |
| Wistar Rata | HP | Boyd-Kimball et al. 2005c | ||
| Malate dehydrogenase | C. elegansb | -- | Boyd-Kimball et al. 2006 | |
| Phosphoglycerate mutase 1 | Wistar Rata | HP | Boyd-Kimball et al. 2005c | |
| Pyruvate dehydrogenase (PDH) (lipoamide) | Wistar Rata | HP | Boyd-Kimball et al. 2005c | |
| Transketolase | C. elegansb | -- | Boyd-Kimball et al. 2006 | |
| Excitotoxicity | Glutamine Synthetase | Wistar Rata | Cortex | Boyd-Kimball et al. 2005c |
| Synaptic plasticity, vesicle-mediated transport, and cell structure | actin | C. elegansb | -- | Boyd-Kimball et al. 2006 |
| β-synuclein | Wistar Rata | HP | Boyd-Kimball et al. 2005c | |
| Fascin actin bundling protein | Canineb | -- | Opii et al. 2008 | |
| Myosin regulatory light chain | C. elegans | -- | Boyd-Kimball et al. 2006 | |
| Neurofilament triplet L | Canineb | -- | Opii et al. 2008 | |
| α-/β-tubulin | Wistar Rata | Cortex | Boyd-Kimball et al. 2005c | |
| Protein Synthesis | Elongation factor 1 γ | C. elegansb | -- | Boyd-Kimball et al. 2006 |
| Protein Folding and Degradation | HSP60 | Wistar Rata | NBM | Boyd-Kimball et al. 2005c |
| Proteasome α-subunit | C. elegansb | -- | Boyd-Kimball et al. 2006 | |
| Proteasome β-subunit | C. elegansb | -- | Boyd-Kimball et al. 2006 | |
| Signal Transduction | 14-3-3ζ | Wistar Rata | HP, NBM | Boyd-Kimball et al. 2005c |
Note: HP, hippocampus; NBM, nucleus basalis magnocellaris
a
ICV injection of Aβ(1–42) into the NBM with analysis 7 days post injection;
b
expresses Aβ(1–42) with human amino acid sequence.