Table 3:
Oxidatively Modified Proteins Identified in AD mouse models
| Function | Protein | Transgenic Mouse Model | Age (months) | Oxidative Modification | References |
|---|---|---|---|---|---|
| Cellular Redox Homeostasis and Detoxification Defense | Peroxiredoxin 2 (Prx2) | SAMP8a | 12 | C↓ | Poon et al. 2005 |
| Energy Metabolism | Aconitase | 3×Tg-AD | 3 | C↑ | Shen et al. 2015 |
| Aldolase | SAMP8a | 12 | C↓ | Poon et al. 2005 | |
| ATP Synthase | APP/PS1 KI | 12,15 | C↑ | Sultana et al. 2011a | |
| Creatine Kinase (CK) | SAMP8 | 12 | C↑ | Poon et al. 2004 | |
| α-enolase | APP/PS1 KI | 6,9,12,15 | C↑ | Sultana et al. 2011a | |
| 3×Tg-AD | 3 | C↑ | Shen et al. 2015 | ||
| SAMP8b | 12 | N↑ | Fiorini et al. 2013 | ||
| Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) | 3×Tg-AD | 3 | C↑ | Shen et al. 2015 | |
| Isocitrate dehydrogenase (IDH) | SAMP8b | 12 | N↑ | Fiorini et al. 2013 | |
| Lactate dehydrogenase (LDH) | SAMP8b | 12 | N↑ | Fiorini et al. 2013 | |
| SAMP8 | 12 | C↑ | Poon et al. 2004 | ||
| Malate dehydrogenase (MDH) | 3×Tg-AD | 3 | C↑ | Shen et al. 2015 | |
| Phosphoglycerate kinase (PGK) | 3×Tg-AD | 3 | C↑ | Shen et al. 2015 | |
| Pyruvate dehydrogenase (PDH) (E1) | APP/PS1 KI | 6 | C↑ | Sultana et al. 2011a | |
| Synaptic plasticity, vesicle-mediated transport and cell structure | β-synuclein | APP/PS1 KI | 12 | C↑ | Sultana et al. 2011a |
| Dihydropyrimidinase-related protein 1 (DRP-1) | SAMP8b | 12 | N↑ | Fiorini et al. 2013 | |
| Dihydropyrimidinase-related protein 2 (DRP-2) | SAMP8 | 12 | C↑ | Poon et al. 2004 | |
| SAMP8b | 12 | N↓ | Fiorini et al. 2013 | ||
| Dynamin-1 | SAMP8b | 12 | N↑ | Fiorini et al. 2013 | |
| Vesicle-fusing ATPase | SAMP8b | 12 | N↑ | Fiorini et al. 2013 | |
| Septin 11 | SAMP8b | 12 | N↑ | Fiorini et al. 2013 | |
| Neuropolypeptide h3 (PEBP1) | J20 | 9 | N↓ | Robinson et al. 2011 | |
| β-Actin | APP/PS1 KI | 1,15 | C↑ | Sultana et al. 2011a | |
| Actin related protein 2 | SAMP8b | 12 | N↑ | Fiorini et al. 2013 | |
| Coronin1A | SAMP8a | 12 | C↓ | Poon et al. 2005 | |
| Neurofilament light polypeptide | 3×Tg-AD | 3 | C↑ | Shen et al. 2015 | |
| α-Spectrin 2 | SAMP8 | 12 | C↑ | Poon et al. 2004 | |
| Tubulin β−2A chain | 3×Tg-AD | 3 | C↑ | Shen et al. 2015 | |
| Neuroinflammation | GFAP | SAMP8b | 12 | N↑ | Fiorini et al. 2013 |
| Protein Folding and Degradation | HSP90AB1 | 3×Tg-AD | 3 | C↑ | Shen et al. 2015 |
| Protein disulfide-isomerase A3 | 3×Tg-AD | 3 | C↑ | Shen et al. 2015 | |
| T-complex protein 1 subunit ε | 3×Tg-AD | 3 | C↑ | Shen et al. 2015 | |
| Signal Transduction | 14-3-3ζ/δ/γ | APP/PS1 KI | 1,9,12,15 | C↑ | Sultana et al. 2011a |
| 14-3-3ζ/δ | 3×Tg-AD | 3 | C↑ | Shen et al. 2015 | |
| Pin1 | J20 | 9 | N↓ | Robinson et al. 2011 | |
| APP/PS1 KI | 9,12,15 | C↑ | Sultana et al. 2011a |
Note: C, carbonylation; N, nitration;
↑
oxidative modification was significantly increased;
↓
oxidative modification was significantly decreased;
a
Antisense Oligonucleotide directed against Aβ region of APP gene;
b
Antisense Oligonucleotide directed against PS-1 gene;