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. 2019 Mar 8;10:118. doi: 10.3389/fendo.2019.00118

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Copyright © 2019 Chen, Li, Wang, Song, Li, Xie, Li, Chen, Ma, Chen, Lv, Li and Ge.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FGF1 affects medium testosterone levels in vitro. EDS-treated seminiferous tubules were cultured in LCDM for 14 days. (A) the effects of different concentrations of FGF1 on medium testosterone (T) levels; (B), medium testosterone (T) levels after control (CON, no agent), 10 ng/ml FGF1 (FGF1), 1 μM PD173074 (a FGFR1 antagonist, PD), and 10 ng/ml FGF1 + 1 μM PD (FGF1 + PD) for 14 days. Mean ± SEM, n = 12. Identical letters designate no significant differences at P < 0.05 between two groups.