Table 3.
Univariate and multivariate Cox regression analysis.
|
Univariate analysis |
Unit variable increase | LC | DFS | DSS | OS | ||||
|---|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | ||
| Age | years | 1.00 (0.98–1.01) |
0.547 | 1.00 (0.99–1.01) |
0.967 | 1.00 (0.99–1.01) |
0.930 | 1.02 (1.01–1.03) |
< 0.001 |
| Histology | 0.016 | 0.014 | 0.199 | 0.077 | |||||
| squamous vs. adeno |
0.48 (0.29–0.81) |
0.006 | 0.54 (0.3–0.82) |
0.004 | 0.65 (0.41–1.05) |
0.077 | 0.63 (0.42–0.94) |
0.025 | |
| other vs. adeno | 0.77 (0.32–1.86) |
0.559 | 0.72 (0.34–1.55) |
0.77 (0.34–1.76) |
0.541 | 0.74 (0.37–1.49) |
0.403 | ||
| FIGO stage | < 0.001 | < 0.001 | < 0.001 | < 0.001 | |||||
| IIA+ IIB vs. IB | 1.15 (0.58–2.28) |
0.695 | 1.32 (0.76–2.31) |
0.322 | 1.34 (0.72–2.50) |
0.349 | 1.70 (0.99–2.94) |
0.057 | |
| IIIA + IIIB vs. IB | 2.72 (1.38–5.39) |
0.004 | 2.63 (1.50–4.60) |
0.001 | 2.98 (1.60–5.53) |
0.001 | 3.36 (1.94–5.84) |
< 0.001 | |
| IVA + IVB vs. IB | 1.38 (0.58–3.33) |
0.470 | 1.69 (0.85–3.35) |
0.135 | 2.10 (1.00–4.40) |
0.050 | 2.81 (1.49–5.29) |
0.001 | |
| Lymphadenopathy | 0.201 | 0.360 | 0.268 | 0.587 | |||||
| iliac vs. negative | 1.38 (0.93–2.06) |
0.114 | 1.22 (0.87–1.69) |
0.249 | 1.14 (0.79–1.64) |
0.482 | 0.85 (0.63–1.16) |
0.853 | |
| PAO vs. negative | 0.92 (0.51–1.66) |
0.768 | 1.29 (0.85–1.97) |
0.231 | 1.43 (0.93–2.21) |
0.106 | 0.97 (0.66–1.42) |
0.966 | |
| Time interval | minutes | 1.00 (0.99–1.01) |
0.565 | 1.00 (0.99–1.01) |
0.597 | 1.00 (0.99–1.01) |
0.655 | 1.00 (0.99–1.00) |
0.855 |
| CEM43T90 | minutes | 0.93 (0.87–1.00) |
0.035 | 0.95 (0.90–1.00) |
0.053 | 0.96 (0.91–1.02) |
0.155 | 1.01 (0.97–1.01) |
0.491 |
| TRISE | degrees Celsius | 0.67 (0.52–0.86) |
0.002 | 0.75 (0.60–0.92) |
0.006 | 0.73 (0.58–0.91) |
0.006 | 0.80 (0.65–0.96) |
0.016 |
| IGBT use | yes vs. no | 0.41 (0.21–0.82) |
0.011 | 0.56 (0.34–0.91) |
0.020 | 0.38 (0.20–0.73) |
0.003 | 0.43 (0.25–0.74) |
0.002 |
| MULTIVARIATE ANALYSIS | |||||||||
| Histology | 0.010 | 0.024 | n.s. | 0.071 | |||||
| squamous vs. adeno |
0.45 (0.26–0.78) |
0.004 | 0.53 (0.33–0.85) |
0.008 | 0.603 (0.39–0.94) |
0.024 | |||
| other vs. adeno | 0.65 (0.29–1.46) |
0.587 | 0.74 (0.34–1.62) |
0.454 | 0.75 (0.36–1.54) |
0.428 | |||
| FIGO stage | 0.010 | 0.002 | < 0.001 | < 0.001 | |||||
| IIA+ IIB vs. IB | 1.50 (0.72–3.11) |
0.278 | 1.69 (0.92–3.10) |
0.090 | 1.82 (0.92–3.61) |
0.086 | 1.98 (1.10–3.58) |
0.024 | |
| IIIA + IIIB vs. IB | 2.80 (1.34–5.84) |
0.006 | 2.86 (1.55–5.27) |
0.001 | 3.54 (1.78–7.07) |
< 0.001 | 3.22 (1.77–5.85) |
< 0.001 | |
| IVA + IVB vs. IB | 1.74 (0.70–4.30) |
0.233 | 2.03 (0.98–4.17) |
0.055 | 2.45 (1.11–5.37) |
0.026 | 3.38 (1.74–6.60) |
< 0.001 | |
| Lymphadenopathy | 0.031 | 0.051 | 0.011 | n.s. | |||||
| iliac vs. negative | 1.81 (1.16–2.81) |
0.009 | 1.42 (0.99–2.05) |
0.059 | 1.48 (0.99–2.20) |
0.057 | |||
| PAO vs. negative | 1.29 (0.70–2.39) |
0.419 | 1.65 (1.05–2.58) |
0.031 | 2.00 (1.25–3.19) |
0.004 | |||
| TRISE | degrees celsius | 0.65 (0.50–0.84) |
0.001 | 0.72 (0.58–0.89) |
0.003 | 0.71 (0.57–0.90) |
0.004 | 0.79 (0.65–0.96) |
0.019 |
| IGBT use | yes vs. no | 0.43 (0.21–0.97) |
0.019 | 0.58 (0.35–0.96) |
0.035 | 0.41 (0.21–0.78) |
0.007 | 0.46 (0.27–0.81) |
0.006 |
| CEM43T90* | minutes | 0.92 (0.85–0.99) |
0.019 | 0.94 (0.89–0.99) |
0.019 | 0.94 (0.89–1.00) |
0.051 | n.s. | |
Cox proportional hazard analysis for LC, DFS, DSS, and OS.
*
In multivariate analysis using CEM43T90, other factors showed similar results compared to results shown for TRISE.