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. 2019 Mar 8;13:201. doi: 10.3389/fnins.2019.00201

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Copyright © 2019 Hass and Barnstable.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Increased Ucp2 expression in RGCs but not astrocytes and müller glia decreases retinal ganglion cell loss. (A) Difference IOP between bead- and PBS-injected eyes before and following intraocular surgery. Beads injection elevated IOP over a 30-day period in Ucp2^KI (n = 11), Ucp2^KI; Gfap-creER^T2 (n = 6), Ucp2^KI; Thy1-creER^T2 (n = 9) eyes. (B) Percentage RGC survival in retinal whole-mounts from bead-injected eyes, relative to retinas of PBS-injected contralateral control eyes. (C) Representative images of retinal whole-mounts labeled for RBPMS, quantified in B. ^∗∗p < 0.01.