Fig. 6.

Carboplatin–paclitaxel combination therapy impacts immune cell signatures during response to therapy. a Immune cell signatures for cells typically associated with antigen presentation function are shown for KPB1A and KPB1B tumors across the specified therapeutic timepoints. Each immune cell signature is published as follows: Th1-polarized macrophages [32], activated dendritic cells [33], and the B-cell cluster signature [32]. b Immune cell signatures for T-cell subsets: Th1 T-Cells [26], Gamma-delta T-cells [33], and the CD8+T-cell signature [32]. c Other signatures for immune cells with anti-tumor functions are shown: plasma cells [33], activated NK cells [33], and neutrophils [33]. For each tumor line and time point, the sample sizes are as follows: KPB1A-no treatment n = 7, 24 h treated n = 10, 3 day treated n = 4, 6 day treated n = 4, and 10 day treated n = 7; KPB1B-no treatment n = 6, 24 h treated n = 10, 3 day treated n = 4, 6 day treated n = 4, and 10 day treated n = 7. Statistical analysis was conducted using an ordinary one-way ANOVA with KPB1A and KPB1B timepoints separately