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. 2018 Mar 14;10(4):272–284. doi: 10.1007/s13238-018-0518-7

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Analysis of METTL3 ZFD structure with small-angle X-ray scattering. (A) Comparison between the experimental (shown as gray dots for the truncated version of ZFD for residues 258–338) and calculated (shown as red lines) scattering profiles. The scattering curves are calculated for all 25 conformers in the bundle. (B) Comparison between the experimental (shown as black line) and calculated (shown as red lines) paired distance distribution P(r) functions. The P(r) profile suggests that the C-terminal tail of the ZFD likely interconverts between open and closed conformations