Table 6.
Cox regression analyses of SCZ risk among patients with RA and non-RA controls stratified by gender and age.
| Variable | RA | Crudeb HR (95% CI) | Adjustedc HR (95% CI) | p-value for interaction | |||||
|---|---|---|---|---|---|---|---|---|---|
| No | Yes | ||||||||
| SCZ | Person-years | IRa | SCZ | Person-years | IRa | ||||
| Total | 77 | 793424 | 0.97 | 14 | 183614 | 0.76 | 0.79 (0.45–1.39) | 0.77 (0.44–1.37) | |
| Gender | 0.09 | ||||||||
| Female | 65 | 614213 | 1.05 | 9 | 143470 | 0.62 | 0.59 (0.30–1.19) | 0.60 (0.30–1.20) | |
| Male | 12 | 179211 | 0.67 | 5 | 40144 | 1.24 | 1.86 (0.66–5.29) | 1.66 (0.57–4.83) | |
| Age group, year | 0.65 | ||||||||
| <25 | 0 | 43738 | 0 | 1 | 10173 | 0.98 | — | — | |
| 25–50 | 32 | 301233 | 1.06 | 5 | 70500 | 0.70 | 0.66 (0.26–1.69) | 0.60 (0.23–1.56) | |
| >50 | 45 | 448453 | 1.00 | 8 | 102942 | 0.77 | 0.79 (0.37–1.67) | 0.78 (0.36–1.66) | |
aPer 10,000 person-years; bRelative hazard ratio; cMutually adjusted for SCZ, gender, age, and comorbidities in Cox regression analyses. SCZ: schizophrenia; RA: rheumatoid arthritis; IR: incidence rates; HR: hazard ratio; CI: confidence interval.