Fig. 6. Effects of PCNP on the growth, proliferation index (PI), and MVD of A549 and H1299 xenograft tumors in nude mice.

a Representative xenografts dissected from different groups of nude mice were shown. b, c The tumor volume of each group was measured every day and the tumor volume doubling time (TVDT) was calculated. d, e The tumors were weighed and the inhibition rates of tumor growth were calculated. f, g The body weight change curve of each group during the experiment and the body weight of each group on the first day (day 0) and the last day (day 28). h, i, j Representive photographs of hematoxylin and eosin (HE), Ki67, and cluster of differentiation 31 (CD31) staining in A549 and H1299 xenograft tumors; original magnification ×400. k, l The PI and MVD were calculated. Values are presented as mean ± SEM (n = 6); **P < 0.01 compared with the Mock group; ^##P < 0.01 compared with the sh-Scb group