Table 3.

Summary of the results of ^#multivariate logistic regression identifying subjects with active PTB associated with multiple predictors in the derivation cohort. (N = 259).

Term	Estimated β (SE)	Estimated Odds Ratio [95% CI]	P-value	Relative Scorea
HRCT model (variables: COPD, Hypoalbuminemia, Cluster nodules/mass s1, s2, s1 + 2, S3, Consolidation s6)
Cluster nodules/mass s1, s2, s1 + 2, S3 (RUL/LUL)	5.376 (1.39)	216.174 [14.168–3298.488]	0.000*	2
Consolidation s6	3.006 (0.969)	21.977 [2.2382–202.74]	0.002*	1
after #multivariate logistic regression, the variables (e.g. COPD, Hypoalbuminemia) with P values > 0.05, the relative score of these 2 variables set as 0
CXR  + Hypoalbuminemia model (variables: COPD, Hypoalbuminemia, Consolidation/patch/nodules RUL/LUL)
Hypoalbuminemia	2.323 (0.509)	10.207 [3.761–27.7]	<0.001	1
Consolidation/patch/nodules RUL/LUL	2.212 (0.542)	9.13 [3.15–26.40]	<0.001*	1
afte r#multivariate logistic regression, the variable (e.g. COPD) with P value > 0.05, the relative score of this variable set as 0

^&Other variables of the *P value > 0.05 or *frequency < 50% in Tables 1 and 2 (before HRCT/CXR). The relative score of these variables set as 0 in [HRCT] model and [CXR + Hypoalbuminemia] model.

*Statistically significant (p < 0.05). SE, standard error.

^#Only the P value < 0.05 and the frequency > 50% in the symptom/sign, underlying disease of Table 1 (^☆before patients received the HRCT and CXR) and finding of HRCT(CXR) of Table 2 (e.g. COPD, Hypoalbuminemia, cluster nodules/mass s1, s2, s1 + 2, s3 Consolidation s6 in HRCT, consolidation/patch/nodules in CXR) were enrolled into the multivariate logistic regression.

^aAfter the multivariate logistic regression only the variable keep the P value < 0.05 (cluster nodules/mass s1, s2, s1 + 2, s3 and consolidation s6) in HRCT model; (consolidation/patch/nodules and Hypoalbuminemia) in [CXR + Hypoalbuminemia] model were enrolled into the score system. In the [HRCT] model, the relative score is given as 1, if β value > 0 < 5 and the relative score is set as 2, if β value ≥ 5. In the [CXR + Hypoalbuminemia] model, the relative score is given as 1, if β value greater than 0 and less than 5.

RUL: s1 + s2 + s3; LUL: s1 + 2 + s3; RML: s4 + s5, LingL: Ls4 + s5; s6: superior segment of right or left lower lobe (RLL/LLL).

^&Before the multivariate logistic regression, the *P value > 0.05 such as variable of symptom/sign in Table 1 (e.g. age, sex, fever, cough for >2 weeks, dyspnea, body weight loss, weakness) or HRCT (e.g. consolidation of any segment of both lobes except of the s6, tree-in-bud, centrilobular nodules, bronchial thickening, ground-glass opacity) or CXR morphology (e.g., consolidation/patch/nodules of right/left lower lung field, consolidation≥3) or the [*frequency < 50%] such as the variables of HRCT (e.g. cavitation of any segment of both lobes, clusters nodules/mass of any segment of both lobes except of the right/left upper lobe, pleural effusion) or CXR morphology (e.g. cavitation of right/left upper or lower lung field, military nodules) in the Table 2 were also set the relative score as 0.

CXR, chest X-ray; G1, iSN-aPTB; G2, [non-aPTB-PD]; HRCT, high-resolution computed tomography; s1 = apical segment; s2 = posterior segment right upper lobe; s1 + s2 = apico-posterior segment left upper lobe; s3 = anterior segment; s6 = superior segment of right or left lower lobe.

G1, initial smear-negative active pulmonary tuberculosis (iSN-aPTB); G2 = non-aPTB pulmonary diseases [non-aPTB-PD].